Our aim is to understand how inheritance and the environment together affect complex biological networks underlying disease initiation and progression in neurodegeneration. To this end, we are generating and integrating multi-omic and clinicopathological data from highly characterized patient cohorts with neurodegenerative disorders and neurologically healthy aging. We employ a broad arsenal of supervised and unsupervised methods to integrate genomic, epigenomic, transcriptomic and proteomic information from specific tissues and/or cell populations of patients and healthy controls. Emerging molecular fingerprints from these analyses are being further studied in our lab in order to identify and develop disease biomarkers and therapeutic targets.